Topic: Astrocytic mGluR5-dependent calcium hyperactivity promotes Aβ pathology and cognitive impairment

Time: March 31, 2025 (Monday) 10:00-11:30 AM

Location: Smart Classroom 404, Zhizhen Building, Ningbo University Health Science Center

Speaker: Prof. Yi Shen, PhD Supervisor

Affiliations:

School of Brain Science and Brain Medicine, Zhejiang University

Honorary Mentor, Chu Kochen College, Zhejiang University

Deputy Director, National Human Brain Tissue Resource Center for Health and Disease (formerly known as the Chinese Brain Bank, Zhejiang University School of Medicine)

Concurrent Professor, The Second Affiliated Hospital, Zhejiang University School of Medicine

Honorary Lecturer/PhD Supervisor Status, University of Edinburgh, UK

Biography:

Prof. Yi Shen received his Bachelor’s degree from the College of Life Sciences, Zhejiang University (1999-2003), and his PhD from Zhejiang University School of Medicine under the supervision of Prof. Jianhong Luo (2003-2008). He completed postdoctoral training at the University of California, Los Angeles (UCLA) from 2008 to 2011. He joined Zhejiang University as a Lecturer in December 2011, was promoted to Associate Professor and qualified as a PhD supervisor in April 2012, and became a Full Professor in January 2023.

His research focuses on elucidating the mechanisms of neuroimmune activation in regulating synapse development, function, and the pathogenesis of related brain disorders. He serves as Principal Investigator (PI) of one sub-project under the National Key R&D Program of China (Ministry of Science and Technology, 2030 Major Projects), four projects funded by the National Natural Science Foundation of China (NSFC), and one project by the Natural Science Foundation of Zhejiang Province. He has published over 10 high-impact research articles as first and/or corresponding (including co-corresponding) author in prestigious journals such as Nature Neuroscience, Nature Communications, Glia, The Journal of Cell Biology, and The Journal of Neuroscience.